Scientific background - amyloid-related toxicity and inflammation

It is estimated that diseases resulting from amyloidosis affect over 50 million people in the developed world today and the prevalence of all ageing-related diseases is likely to double by 2030. A variety of seemingly unrelated degenerative diseases have all been linked to a fundamental pathogenic process of protein/peptide aggregation of amyloid-like proteins. In each case, a specific protein or peptide clumps together to form toxic soluble oligomers and/or insoluble "amyloid-like" fibres that can produce inappropriate inflammation. Toxic soluble oligomers and inflammation are widely believed to cause the progressive degeneration of the cells associated with these diseases (see diagram below).

Senexis is currently focused on of four of those ageing-related diseases: Alzheimer's disease, diabetes, Dialysis Related Amyloidosis and Inclusion Body Myositis.

The diagram above illustrates the formation of the soluble toxic species of amyloid